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Pharmaceutical Intermediate
 
    Product Name or CAS NO.
     
 
 
Pharmaceutical Intermediate
 

Disodium pamidronate
Synonyms Disodium 3-amino-1-hydroxy-propylidenebisphosphonate
CAS No. 109552-15-0
Structure
Specification Appearance     White or almost white, crystalline powder. 
Solubility    Soluble in water and in 2M sodium hydroxide; Sparingly soluble in 0.1M hydrochloric acid; 
Practically insoluble in organic solvents. 
Idmentification    A.  IR spectrum is concordant with RS 
    B. A 5% w/v solution yield reactioncharacteristic of sodium salts. 
pH    7.8~8.8 
Clarity and colour of solution    A 2.0% w/v solution is clear and not more intensely Coloured than reference solution Y6 
Heavy metals ,ppm   10 Max.
ß-Alanine ,%   0.5Max. 
Phosphate,%    0.5Max.
Phosphite,%    0.5Max. 
Water(KF)    23.0%-27.0% 
Assay    NLT98%&NMT102.0%(anhydrous substance) 
Application Applied as Pharmaceutical Intermediate
Remaks


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